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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DISC1
All Species:
22.73
Human Site:
Y370
Identified Species:
62.5
UniProt:
Q9NRI5
Number Species:
8
Phosphosite Substitution
Charge Score:
0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NRI5
NP_001012975.1
854
93611
Y370
D
A
V
E
N
D
D
Y
D
K
A
E
T
L
Q
Chimpanzee
Pan troglodytes
XP_001151459
858
94064
Y370
D
A
V
E
N
D
D
Y
D
K
A
E
T
L
Q
Rhesus Macaque
Macaca mulatta
NP_001107827
854
93125
Y370
D
A
V
E
N
D
D
Y
D
K
A
E
T
L
Q
Dog
Lupus familis
XP_546088
886
96973
Y399
K
A
I
E
D
D
D
Y
D
K
A
E
A
L
R
Cat
Felis silvestris
Mouse
Mus musculus
Q811T9
852
92506
Y371
K
V
V
E
D
G
D
Y
D
T
A
E
T
L
R
Rat
Rattus norvegicus
Q810H6
846
92545
Y363
K
A
V
E
D
G
D
Y
D
M
A
E
T
L
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Q9PTD7
1360
158447
D564
E
E
V
Q
D
E
L
D
E
V
L
Q
I
R
Q
Zebra Danio
Brachydanio rerio
NP_001135735
994
112198
Y509
K
A
I
L
D
D
D
Y
D
T
A
E
R
F
G
Tiger Blowfish
Takifugu rubipres
NP_001167643
596
65868
I177
S
Q
D
P
E
P
L
I
H
K
K
G
P
N
S
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.1
94.3
69
N.A.
56.4
54.9
N.A.
N.A.
N.A.
20.2
25.2
22.7
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
97.6
96.8
75.7
N.A.
70.7
68.9
N.A.
N.A.
N.A.
35.4
41.8
36
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
66.6
N.A.
60
66.6
N.A.
N.A.
N.A.
13.3
46.6
6.6
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
86.6
N.A.
73.3
80
N.A.
N.A.
N.A.
53.3
60
6.6
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
67
0
0
0
0
0
0
0
0
78
0
12
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
34
0
12
0
56
56
78
12
78
0
0
0
0
0
0
% D
% Glu:
12
12
0
67
12
12
0
0
12
0
0
78
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
12
0
% F
% Gly:
0
0
0
0
0
23
0
0
0
0
0
12
0
0
12
% G
% His:
0
0
0
0
0
0
0
0
12
0
0
0
0
0
0
% H
% Ile:
0
0
23
0
0
0
0
12
0
0
0
0
12
0
0
% I
% Lys:
45
0
0
0
0
0
0
0
0
56
12
0
0
0
0
% K
% Leu:
0
0
0
12
0
0
23
0
0
0
12
0
0
67
0
% L
% Met:
0
0
0
0
0
0
0
0
0
12
0
0
0
0
0
% M
% Asn:
0
0
0
0
34
0
0
0
0
0
0
0
0
12
0
% N
% Pro:
0
0
0
12
0
12
0
0
0
0
0
0
12
0
0
% P
% Gln:
0
12
0
12
0
0
0
0
0
0
0
12
0
0
45
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
12
12
34
% R
% Ser:
12
0
0
0
0
0
0
0
0
0
0
0
0
0
12
% S
% Thr:
0
0
0
0
0
0
0
0
0
23
0
0
56
0
0
% T
% Val:
0
12
67
0
0
0
0
0
0
12
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
78
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _